Teaching
The Biopharmacy group is committed to excellence in teaching.
The contents of the lectures and practical course are
Biopharmacy
- introduction to biopharmacy in general and to basic pharmacokinetics
- interpretation of concentration/time profiles
- competence for designing therapeutic regimens
- risk assessment in individuals with monotherapies as well as in the cases of comedication with two or more drugs
- potential of pharmacokinetics for individual drug therapy and for the development of adequate drug formulations
Biotransformation of Drugs and Xenobiotics
- introduction to drug and xenobiotic metabolism reactions and the responsible enzymes
- recognition of potentially toxic metabolites and potentially toxiphoric groups in a molecule
- mechanisms of bioactivation and toxification
- introduction to genetic variabilities in drug metabolism and their consequences
- introduction to inter-individual variabilities in drug metabolism, including drug-drug and food-drug interactions and consequences thereof
Laboratory Course in Biopharamcy
- preparation of liver microsomes and study of a metabolism reaction
- determination of n-octanol/buffer partition coefficients, logP, logD
- characterization of serum albumin binding of a drug by equilibrium dialysis